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Abstract #4493

A Combined Analysis of the Non-Gaussian Diffusion Methods in Monte Carlo Simulations, Anisotropic Fibre Phantoms, and in in vivo Human Brain Tissues

Farida A Grinberg 1 , Ezequiel Farrher 1 , Ivan I Maximov 1 , and N. Jon Shah 1,2

1 INM-4, Forschungszentrum Juelich, Juelich, Germany, 2 Department of Neurology, RWTH Aachen University, Aachen, Germany

This work provides a comparative analysis of the four non-monoexponential functions in fitting the diffusion response in a) the Monte Carlo diffusion simulations in a set of cylindrical objects, b) synthetic fibre phantoms with parallel and crossing fibres, and c) in vivo human brain tissue. All functions including the diffusion kurtosis, stretched-exponential, the lognormal- and gamma-distribution functions were shown to provide complimentary information and different contrasts in parameter maps.

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