Abstract #4489
High Resolution Diffusion Imaging of the Brain Stem for Non-Gaussian Diffusion Analysis at High b-Values
Yi Sui 1,2 , Frederick C. Damen 1,3 , and Xiaohong Joe Zhou 1,4
1
Center for MR Research, University of
Illinois at Chicago, Chicago, Illinois, United States,
2
Department
of Bioengineering, University of Illinois at Chicago,
Chicago, Illinois, United States,
3
Department
of Radiology, University of Illinois Hospital & Health
Sciences System, Chicago, Illinois, United States,
4
Departments
of Radiology, Neurosurgery and Bioengineering,
University of Illinois Hospital & Health Sciences
System, Chicago, Illinois, United States
An integrated high-resolution, multi-b-value diffusion
acquisition approach has been developed with reduced FOV
and phase-sensitive signal averaging. Using this
approach, distortion-free brain stem diffusion images
with an in-plane resolution of ~0.60.6 mm
2
have
been obtained at b-values up to 4000 s/mm
2
and
successfully fitted to a non-Gaussian diffusion model
(Fractional Order Calculus model). This study
demonstrates the potential for extending the
applications of high b-value non-Gaussian diffusion
models to fine brain structures.
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