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Abstract #4486

Two-component Low Q-space Diffusion MRI in Evaluation of Spinal Cord in Patients with Cervical Spondylosis in Vivo: a Feasibility Study

Masaaki Hori 1 , Koji Kamagata 1 , Mariko Yoshida 1 , Nozomi Hamasaki 2 , Shuji Sato 2 , Kouhei Kamiya 1,3 , Yuriko Suzuki 4 , Michimasa Suzuki 1 , and Shigeki Aoki 1

1 Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2 Juntendo University Hospital, Tokyo, Japan, 3 Radiology, The University of Tokyo, Tokyo, Japan, 4 Philips Electronics Japan, Ltd, Tokyo, Japan

We investigate two-component low q-space diffusion MRI in evaluation of microstructural changes in the spinal cord in patients with cervical spondylosis in vivo, as a feasibility study. Five patients were enrolled in this study. There were significant differences in root mean square displacement of water molecules in extra- and intra- cellular spaces between compressed and uncompressed area in the spinal cords. More studies of the imaging pathological correlation and improvement of image quality are needed; this technique has the potential to provide new information in patients with spinal cord in vivo.

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