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Abstract #4475

Human Brain Intravoxel Incoherent Motion (IVIM) : Optimized set-up for clinical investigation

Alberto Ciarmatori 1,2 , Elisa Cenacchi 1 , Tiziana Costi 1 , and Luca Nocetti 1

1 Medical Physics Department, University Hospital "Policlinico", Modena, Italy, 2 Medical Physics School, University "Alma Mater Studiorum", Bologna, Italy

This study focused on separation of vascular and non-vascular component of DWI signal decay. Brain scans were performed using a 3T whole body MR on six healthy volunteers. DWIs with multiple b-values (0-5-10-20-30-40-50-75-100-150-200-300-500-1000 s/mm2) were obtained. Datas were fitted with a biexponential function with Diffusion Coefficient and Perfusion Fraction obtained from high-b (>250 s/mm2) monoexponential fit. A temporal optimized (6 min) sequence was found . Significative differences were observed D and standard ADC as well as between gray matter and white matter diffusion parameters. In particular D* of gray matter resulted significantly greater than in white matter.

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