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Abstract #4461

Correction of Off-resonance Distortions in In-vivo Cardiac Diffusion Tensor Imaging

Jack Harmer 1 , Rachel W Chan 2 , Christian T Stoeck 3 , Constantin V Deuster 3 , David Atkinson 2 , and Sebastian Kozerke 1,3

1 Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom, 2 Centre for Medical Imaging, University College London, London, Greater London, United Kingdom, 3 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Advances in diffusion acquisition schemes employing stimulated echo modes now allow diffusion tensor imaging of the beating heart. However these pulse sequences almost invariably use single shot EPI readout modules that are extremely sensitive to magnetic field inhomogeneities. We demonstrate the feasibility of acquiring fully sampled single-shot in-vivo cardiac DTI data at 3T, in order to maximise SNR, by employing off-resonance correction as part of the reconstruction process. We demonstrate that such correction can be used to accurately reconstruct the correct geometry in areas of severe geometric distortion and signal pileup, whilst still allowing diffusion tensors to be reconstructed.

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