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Abstract #4449

Accelerated human cardiac diffusion tensor imaging using simultaneous multi-slice imaging

Angus Z. Lau 1,2 , Elizabeth M. Tunnicliffe 1 , Robert Frost 3 , Peter J. Koopmans 3 , Damian J. Tyler 1,2 , and Matthew D. Robson 1

1 Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2 Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom, 3 FMRIB Centre, University of Oxford, Oxford, United Kingdom

Remodeling of cardiac fibre structure contributes to impaired cardiac function, and is implicated in the development of cardiac arrhythmias and sudden cardiac death. Diffusion tensor imaging (DTI) allows non-invasive detection of microstructure in vivo, but low SNR leads to long scan times, limiting the patient population which can benefit from such exams. In this abstract, we investigate the feasibility of using simultaneous multi-slice (SMS) excitation to accelerate human DTI of the heart. We demonstrate three-fold scan time reduction of cardiac diffusion measurements, and we anticipate this development will make it practical to incorporate DTI within a comprehensive clinical exam.

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