Correcting for B1 inhomogeneities in post-mortem DWSSFP human brain data at 7T using multiple flip angles

Due to the comparably sized RF wavelength at 7T, human brain imaging suffers from a central bright spot. Here, we investigated the implementation of a multiple flip angle approach to account for this B1 dependent artifact. Data were acquired at 7T of post-mortem human brain using a diffusion weighted steady-state free precession pulse sequence. Two flip angles were chosen using a described optimization method and DTI data were acquired using both. Results demonstrate that the primary diffusion direction was more accurately estimated in gray matter where signal loss due to B1 decreases have made this otherwise difficult to detect.

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