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Abstract #4432

Magnetic Resonance Microscopy of the Drosophila Brain at 10 Micron Isotropic Resolution

Choong Heon Lee 1,2 , Stephen J Blackband 1,2 , and Fernandez-Funez Pedro 1,3

1 Neuroscience, University of Florida, Gainesville, FL, United States, 2 McKnight Brain Institute, Gainesville, FL, United States, 3 Neurology, University of Florida, FL, United States

Understanding the complex brain architecture and functional connectivity using MRI has been a major interest in neuroscience. Based on the capability of MR microscopy to visualize the mammalian and human cells, the desire to map the entire human brain circuit at the resolution high enough to visualize cell-level structures is becoming a reality. Studies of a simpler brain, i.e. Drosophila, are significant due to its high genetic tractability together with high degree of conservation with humans at the genetic and cellular levels. To visualize the neuronal circuitry in the brain, we acquired MRM of it at 10 m isotropic resolution.

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