Abstract #4415
Imaging microstructure: Application of oscillating gradient diffusion sequences on a 3T clinical MRI scanner
Lebina Shrestha Kakkar 1 , David Atkinson 2 , Rachel W Chan 2 , and Ivana Drobnjak 1
1
Center for Medical Image Computing,
University College London, London, United Kingdom,
2
Center
for Medical Imaging, University College London, United
Kingdom
Estimation of brain micro-structure parameters can be
used to improve understanding of neuro-degeneration due
to ageing or dementia. Recent studies show these
estimations are possible using pulsed gradient spin echo
sequences but are more accurately estimated using
trapezoidal oscillating gradient spin echo (tOGSE)
sequences. Here, we implement tOGSEs on a 3T MRI scanner
and test its feasibility by imaging: (1)microcapillaries
(2)an asparagus stem and (3)the corpus callosum of two
healthy volunteers. Their fiber diameters were estimated
using only 5 measurements with the three-stage fitting
model procedure. Our results suggest good agreement with
the ground truth and histology for our phantoms.
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