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Abstract #4323

Novel upper airway compliance measurement using dynamic golden-angle radial FLASH

Ziyue Wu 1 , Yoon-chul Kim 2 , Michael C.K. Khoo 1 , and Krishna S. Nayak 2

1 Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 2 Electrical Engineering, University of Southern California, Los Angeles, CA, United States

Obstructive sleep apnea (OSA) is a disease characterized by repetitive upper airway (UA) narrowing or collapse during sleep. Upper airway compliance, computed as the change in UA cross-sectional area per unit pressure, is a measure of airway collapsibility. Invasive fiberoptic endoscopy has been previously used to measure the UA area and compliance while recently MRI has been used as an alternative noninvasive approach. Current 2D cartesian MRI methods do not provide the spatio-temporal resolution needed to fully resolve UA collapsing dynamics during inspiratory load. We demonstrate the use of dynamic golden-angle radial FLASH imaging in combination with parallel imaging and compressed sensing reconstruction to achieve 1mm spatial and 90ms temporal resolution. From the results, UA dynamic changes can be better visualized and compliance measurement is more accurate with finer temporal and spatial resolution.

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