Abstract #4288
Simultaneous Quantification of T1, T2, Fat Fraction and Off Resonance Frequency Using Phase Sweep SSFP
Sarah Thiesson 1 and Richard B Thompson 1
1
Biomedical Engineering, University of
Alberta, Edmonton, Alberta, Canada
A new approach for simultaneous quantification of water
T1 and T2, fat fraction (FF) and off-resonance frequency
is proposed using a saturation-recovery prepared phase
sweep SSFP method. The signal intensity profile in each
pixel, as a function of RF phase increment (conventional
SSPF has a constant 180 increment), is fit as a
weighted sum of simulated fat and water basis sets
(Bloch equations) to derive T1, T2, FF and
off-resonance. This method was validated with Monte
Carlo simulations (to characterize accuracy and
precession), T1/T2 and fat phantoms, and in-vivo with
characterization of tibialis, gastroc and soleus
skeletal muscle groups
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