Abstract #4263
Selective Imaging of Bound Water in Cortical Bone with Inversion Recovery Prepared Ultrashort Echo Time Sequences
Jiang Du 1 , Shihong Li 1 , Eric Chang 1 , Christine B Chung 1 , and Graeme Bydder 1
1
Radiology, University of California, San
Diego, San Diego, CA, United States
Bone water occurs at various locations and in different
binding states. In normal bone the majority of bone
water is loosely bound to the organic matrix. There is
also a significant amount of free water residing in the
pores of bone which is responsible for nutrient
diffusion and contributes to the viscoelastic properties
of cortical bone. Separation of bound water from free
water is of critical importance since the two make
different contributions to the mechanical properties of
bone. In this study we aimed to investigate the effects
of inversion time (TI) on bone free water signal using
an adiabatic inversion recovery prepared ultrashort echo
time (IR-UTE) sequence on a clinical whole body 3T
scanner.
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