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Abstract #4263

Selective Imaging of Bound Water in Cortical Bone with Inversion Recovery Prepared Ultrashort Echo Time Sequences

Jiang Du 1 , Shihong Li 1 , Eric Chang 1 , Christine B Chung 1 , and Graeme Bydder 1

1 Radiology, University of California, San Diego, San Diego, CA, United States

Bone water occurs at various locations and in different binding states. In normal bone the majority of bone water is loosely bound to the organic matrix. There is also a significant amount of free water residing in the pores of bone which is responsible for nutrient diffusion and contributes to the viscoelastic properties of cortical bone. Separation of bound water from free water is of critical importance since the two make different contributions to the mechanical properties of bone. In this study we aimed to investigate the effects of inversion time (TI) on bone free water signal using an adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequence on a clinical whole body 3T scanner.

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