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Abstract #4258

Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T2 suppression

Luning Wang 1 , Wei Tang 2 , Zipeng Zhen 2 , Hongming Chen 2 , Jin Xie 2 , and Qun Zhao 1

1 Department of Physics and Astronomy, University of Georgia, Athens, Georgia, United States, 2 Department of Chemistry, University of Georgia, Athens, Georgia, United States

Iron oxide nanoparticles (IONPs) have been widely used as a T2/T2* contrast agent in MRI. To avoid signal loss caused by IONPs, pulse sequences, such as Ultrashort TE (UTE) and Sweep Imaging with Fourier Transform (SWIFT), can be implemented to acquire MR signals of IONPs, since the echo times of these sequences are in a few microseconds. But in the UTE and SWIFT images, long T2 tissues and fat may also appear bright, posing a challenge to discriminate IONPs from surrounding tissues. In this work, IONPs were used to target tumor cells grafted in mice. In order to improve the detection specificity of the IONPs delivered to tumors, we hypothesized to embed saturation pulses into the SWIFT sequence to suppress long T2 tissues and fat.

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