Abstract #4242
Simultaneous measurement of total water content and myelin water fraction at 3T: validation in phantoms and results from in vivo human brain
Sandra M. Meyers 1 , Shannon H. Kolind 2 , and Alex L. MacKay 1,3
1
Physics and Astronomy, University of British
Columbia, Vancouver, BC, Canada,
2
Medicine,
University of British Columbia, Vancouver, BC, Canada,
3
Radiology,
University of British Columbia, Vancouver, BC, Canada
Myelin water imaging based on multi-component T2
relaxation is valuable for investigating neurological
diseases such as multiple sclerosis. Myelin water
fraction correlates strongly with histological staining
for myelin, but is also affected by changes in total
water content; therefore, simultaneous measurement of
the two could be a valuable tool for studying brain
disease processes such as edema and demyelination. We
present a T2 relaxation based technique in which myelin
water fraction and water content are measured
simultaneously at 3T. Water content showed excellent
consistency and accuracy (mean error 1.8%) in phantom
validations and in vivo values were consistent with
literature.
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