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Abstract #4242

Simultaneous measurement of total water content and myelin water fraction at 3T: validation in phantoms and results from in vivo human brain

Sandra M. Meyers 1 , Shannon H. Kolind 2 , and Alex L. MacKay 1,3

1 Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2 Medicine, University of British Columbia, Vancouver, BC, Canada, 3 Radiology, University of British Columbia, Vancouver, BC, Canada

Myelin water imaging based on multi-component T2 relaxation is valuable for investigating neurological diseases such as multiple sclerosis. Myelin water fraction correlates strongly with histological staining for myelin, but is also affected by changes in total water content; therefore, simultaneous measurement of the two could be a valuable tool for studying brain disease processes such as edema and demyelination. We present a T2 relaxation based technique in which myelin water fraction and water content are measured simultaneously at 3T. Water content showed excellent consistency and accuracy (mean error 1.8%) in phantom validations and in vivo values were consistent with literature.

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