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Abstract #4237

Magnetization Transfer from Inhomogeneously Broadened Lines (ihMT): Sequence Optimization

Olivier M. Girard 1 , Valentin Prevost 1 , Gopal Varma 2 , David C. Alsop 2 , and Guillaume Duhamel 1

1 CRMBM UMR 7339, CNRS / Aix-Marseille Universit, Marseille, France, 2 Radiology Department, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) imaging has been proposed as a new method for imaging myelinated tissues of the central nervous system. Previous studies have shown promising results on both humans and small animals, at various magnetic field strengths. Various sequence parameters were used and a better understanding of the contrast mechanisms is necessary to further optimize the ihMT effect. Here we characterize the ihMT contrast with respect to the main sequence parameters of a pulsed ihMT preparation module at 1.5T. Very useful information can be derived from presented results in order to optimize ihMT signal and contrast.

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