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Abstract #4235

Specificity of the Inhomogeneous Magnetization Transfer Approach to Myelinated Tissues

Novena A Rangwala 1 , Gopal Varma 1 , Olivier Girard 2 , Guillaume Duhamel 2 , David B Hackney 1 , and David C Alsop 1

1 Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States, 2 CRMBM UMR 7339, CNRS / Aix-Marseille UniversiteĢ, Marseille, France

The inhomogeneous magnetization transfer (IHMT) approach generates images both sensitive and specific to myelinated tissues, especially white matter (WM). We investigated the specificity of IHMT to several tissues and organs not containing myelin. IHMT images were acquired in cervical and thoracic spine and in the abdomen; and IHMT ratios (IHMTR) were compared with MT ratios (MTR) in these tissues. Results showed MTR of 6-27% in different tissues, with MTR ~ 23% in WM. In contrast, IHMTR demonstrated specificity to myelin-containing tissues with 5% in WM, < 2% in gray matter and virtually no IHMTR in other investigated tissues. IHMT may be a reliable marker for myelin in the investigation of WM disorders.

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