Abstract #4208
A comparison of BOLD fMRI, electrophysiology, and oxygen signals in the whisker barrel cortex of the awake rabbit
Daniil P Aksenov 1 , Limin Li 1 , Michael Miller 1 , Gheorghe Iordanescu 1 , Holden M Faber 2 , Robert A Linsenmeier 2 , and Alice M Wyrwicz 1
1
NorthShore University HealthSystem,
Evanston, IL, United States,
2
Northwestern
University, IL, United States
To evaluate the relationship among BOLD fMRI, single
units (SU), local field potentials (LFP), and oxygen
response we obtained fMRI data from rabbits with
chronically implanted electrodes to measure both PO2 and
neuronal responses to whisker stimulation in the cortex.
Striking differences were observed in cortical BOLD,
oxygen, and electrophysiological responses. The shape of
oxygen response more closely resembles the shape of SU
and LFP, whereas the PO2 response exhibits the
post-stimulus offset and subsequent undershoot that
characterize the BOLD response. These differences
reflect the unique physiological characteristics of each
signal.
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