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Abstract #4189

rsfMRI and 1H MRS in sub-chronic phencyclidine (PCP) rat model of cognitive impairment in schizophrenia. A longitudinal study to assess prevention of cognitive impairment deficit

Daniele Procissi 1 , Kathleen Anne Williams 1 , Lakshmi Rajagopal 2 , Yoshihiro Oyamada 2,3 , and Herbert Meltzer 2

1 Radiology, Northwestern University, Chicago, IL, United States, 2 Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, United States, 3 Dainippon Sumitomo Pharma Co., Ltd, Japan

The aim of this work is to use 1H-MRS and fMRI to detect changes in metabolism and connectivity that reflect the behavioral changes and ultimately to evaluate MRI as a potential predictor of successful pharmacological prevention of cognitive impairment in a PCP rat model of schizophrenia .

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