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Abstract #4186

Development of interhemispheric visual integration: a DCM study

Eleonora Fornari 1 , Romana Rytsar 2 , and Maria G Knyazeva 3,4

1 CIBM, Dept. of Radiology, CHUV, Lausanne, Switzerland, 2 Department of Clinical Neuroscience, CHUV, Switzerland, 3 Department of Clinical Neuroscience, CHUV, Lausanne, Switzerland, 4 Department of Radiology, CHUV, Lausanne, Switzerland

In humans, spatial integration develops slowly, continuing through childhood into adolescence. On the assumption that this protracted course depends on the formation of networks with slowly developing top-down connections, we compared effective connectivity in the visual cortex between 13 children (age 713) and 14 adults (age 21-42) using a passive perceptual task. The subjects were scanned while viewing bilateral gratings, which either obeyed Gestalt grouping rules (colinear gratings, CG) or violated them (non-colinear gratings, NG). An analysis of effective connectivity showed that top-down modulatory effects generated at an extrastriate level and interhemispheric modulatory effects between primary visual areas (all inhibitory) are significantly weaker in children than in adults, suggesting that the formation of feedback and interhemispheric effective connections continues into adolescence.

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