Abstract #4186
Development of interhemispheric visual integration: a DCM study
Eleonora Fornari 1 , Romana Rytsar 2 , and Maria G Knyazeva 3,4
1
CIBM, Dept. of Radiology, CHUV, Lausanne,
Switzerland,
2
Department
of Clinical Neuroscience, CHUV, Switzerland,
3
Department
of Clinical Neuroscience, CHUV, Lausanne, Switzerland,
4
Department
of Radiology, CHUV, Lausanne, Switzerland
In humans, spatial integration develops slowly,
continuing through childhood into adolescence. On the
assumption that this protracted course depends on the
formation of networks with slowly developing top-down
connections, we compared effective connectivity in the
visual cortex between 13 children (age 713) and 14
adults (age 21-42) using a passive perceptual task. The
subjects were scanned while viewing bilateral gratings,
which either obeyed Gestalt grouping rules (colinear
gratings, CG) or violated them (non-colinear gratings,
NG). An analysis of effective connectivity showed that
top-down modulatory effects generated at an extrastriate
level and interhemispheric modulatory effects between
primary visual areas (all inhibitory) are significantly
weaker in children than in adults, suggesting that the
formation of feedback and interhemispheric effective
connections continues into adolescence.
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