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Abstract #4172

Aging-Related Reduction in Physiological Signal Contribution to Resting State fMRI

Wendy W Ni 1,2 , Catie Chang 3 , Hesamoddin Jahanian 2 , Gary H Glover 2 , and Greg Zaharchuk 2

1 Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 2 Department of Radiology, Stanford University, Stanford, CA, United States, 3 Advanced MRI Section, LFMI, NINDS, NIH, Bethesda, MD, United States

In this study, we analyze the percentage of resting state BOLD fMRI signal variance attributable to cardiac and respiratory fluctuations, as quantified using the RVHR model, in young normal subjects, elderly subjects with hypertension and chronic kidney disease, and elderly normal subjects. We found a statistically significant difference (p<0.05 with Bonferroni correction) between the young group and each elderly group, but not between the elderly groups. This finding supplements previous work to indicate an association of aging with increased non-physiological fluctuations and/or reduction or change in neurovascular response to physiological stimulation in resting state.

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