Abstract #4166
The Effect of Hypoxia on Resting-State Functional Connectivity in the Human Brain
Ravjit Singh Sagoo 1 , Habib Ganjgahi 2 , Eddie Ng'andwe 1 , Mahmud Saedon 3 , Sarah Wayte 4 , Alex Wright 5,6 , Arthur Bradwell 5,6 , Charles Hutchinson 1,7 , Christopher Imray 3,6 , and Thomas Nichols 2
1
Department of Imaging, University Hospitals
Coventry and Warwickshire NHS Trust, Coventry, United
Kingdom,
2
Department
of Statistics, University of Warwick, Coventry, United
Kingdom,
3
Department
of Surgery, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, United Kingdom,
4
Department
of Medical Physics, University Hospitals Coventry and
Warwickshire NHS Trust, Coventry, United Kingdom,
5
University
of Birmingham, Birmingham, United Kingdom,
6
Birmingham
Medical Research Expeditionary Society, Birmingham,
United Kingdom,
7
University
of Warwick, Coventry, United Kingdom
Rapid ascent to high altitude results in arterial
hypoxaemia, frequently leading to acute mountain
sickness (AMS). The precise mechanisms remain poorly
understood. AMS symptoms can include cognitive and
behavioural changes. We postulate that changes in
cerebral blood flow in response to hypoxia may result in
changes in the brains resting-state functional
connectivity and, therefore, could be studied using
resting-state functional MRI. 12 subjects underwent
serial scans over a 22-hour period of normobaric
hypoxia. The results did not show a global increase in
connectivity to account for the cognitive/behavioural
symptoms. This suggests that alternative
pathophysiological processes may contribute to these
symptoms.
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