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Abstract #4164

Functional connectivity changes as detected by resting-state functional MRI: three cases of patients with focal cerebellar lesions

Giusy Olivito 1,2 , Marco Bozzali 3 , Marco Molinari 2 , Maria Leggio 1,2 , and Mara Cercignani 3,4

1 Department of Psychology, Sapienza University of Rome, Rome, Italy, 2 Ataxia Laboratory, IRCCS Santa Lucia, Rome, Italy, 3 Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy, 4 Clinical Imaging Science Center, Brighton and Sussex Medical School, Brighton, United Kingdom

The cerebellar output channels have been demostrated to be spatially segregated and to focus on functionally distinct cortical systems, supporting the cerebellar role in cognition. 3 cases of patients with left cerebellar lesions were used to demonstrate the sensitivity of resting-state (RS) fMRI to changes in functional connectivity caused by the presence of the lesion. Using the resting-state approach, we were able to define the pattern of connectivity between cerebral cortex and specific cerebellar lobuli. When comparing each patient to the healthy participants, we found different patterns of altered connectivity, involving both contralateral and ipsilateral cortical areas.

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