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Abstract #4154

Frontal Lobe Interhemispheric Connectivity Changes Associated with a Season of High School Football

Fatemeh Mokhtari 1 , Elizabeth Davenport 1 , Jillan Urban 1 , Naeim Bahrami 1 , Christopher Whitlow 2 , Alex Powers 3 , Joel Stitzel 1 , and Joseph Maldjian 2

1 Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, United States, 2 Radiology, Wake Forest University School of Medicine, Winston Salem, NC, United States, 3 Neurosurgery, Wake Forest University School of Medicine, Winston Salem, NC, United States

The primary goal of this study is to determine if cumulative head impacts over a season of high school football has an effect on frontal lobe interhemispheric connectivity. In order to explore this relationship a multiple regression analysis was performed using a linear model of a score of head impacts vs. pre-post difference in fMRI connectivity. Results indicate changes in connectivity of frontal structures in non-concussed subjects during a season of football. These findings add to a growing body of literature that cumulative subconcussive sports-related impacts may have an effect on the brain function.

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