Abstract #4150
Enhanced Functional Connectivity of the Precuneus in Propofol Sedation
Xiaolin Liu 1 , Shi-Jiang Li 1 , and Anthony G. Hudetz 2
1
Biophysics, Medical College of Wisconsin,
Milwaukee, Wisconsin, United States,
2
Anesthesiology,
Medical College of Wisconsin, Milwaukee, Wisconsin,
United States
In this study, we investigated the effects of propofol
sedation on the functional connectivity of the
precuneus, an important neural structure to human
consciousness in the posteromedial parietal cortex. We
found that, contrary to our hypothesis, compared with
wakefulness deep sedation at the point of
unresponsiveness (with auditory stimuli continuously
supplied) is marked by an increase of precuneus
connectivity, particularly in the dorsal medial
prefrontal and visual cortices. The enhanced cortical
connectivity of the precuneus may reflect disconnected
endogenous mentation or dreaming that continues at a
lower rate of energy consumption during the unresponsive
state of propofol sedation.
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