Abstract #4145
The impact of physiological artifact correction on task fMRI group comparison
Steffen Bollmann 1 , Lars Kasper 2 , Carmen Ghisleni 1 , Simon-Shlomo Poil 1 , Peter Klaver 3 , Lars Michels 4 , Dominique Eich-Hchli 5 , Daniel Brandeis 6,7 , and Ruth L. O'Gorman 1
1
Center for MR-Research, University
Children's Hospital, Zurich, Zurich, Switzerland,
2
Institute
for Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland,
3
Institute
of Psychology, University of Zurich, Zrich,
Switzerland,
4
Institute
of Neuroradiology, University Hospital of Zurich,
Zrich, Switzerland,
5
Psychiatric
University Hospital, Zrich, Switzerland,
6
Department
of Child & Adolescent Psychiatry, University of Zurich,
Zrich, Switzerland,
7
Central
Institute of Mental Health Mannheim / Heidelberg
University, Germany
Although physiological noise correction is considered to
be important, there is little known about the impact of
physiological noise correction on task based fMRI group
studies. We therefore investigated the effect of
RETROICOR regressors on a working memory paradigm
comparing healthy adults to patients with ADHD. By
including physiological noise regressors into a
task-based fMRI analysis, we observed an increase in
power in task-relevant regions. At the same time,
presumably spurious activation in areas previously
associated with physiological noise was diminished.
Physiological noise correction for fMRI therefore
appears to reduce the risk of interpreting group
differences caused by physiological artifacts.
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