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Abstract #4145

The impact of physiological artifact correction on task fMRI group comparison

Steffen Bollmann 1 , Lars Kasper 2 , Carmen Ghisleni 1 , Simon-Shlomo Poil 1 , Peter Klaver 3 , Lars Michels 4 , Dominique Eich-Hchli 5 , Daniel Brandeis 6,7 , and Ruth L. O'Gorman 1

1 Center for MR-Research, University Children's Hospital, Zurich, Zurich, Switzerland, 2 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 3 Institute of Psychology, University of Zurich, Zrich, Switzerland, 4 Institute of Neuroradiology, University Hospital of Zurich, Zrich, Switzerland, 5 Psychiatric University Hospital, Zrich, Switzerland, 6 Department of Child & Adolescent Psychiatry, University of Zurich, Zrich, Switzerland, 7 Central Institute of Mental Health Mannheim / Heidelberg University, Germany

Although physiological noise correction is considered to be important, there is little known about the impact of physiological noise correction on task based fMRI group studies. We therefore investigated the effect of RETROICOR regressors on a working memory paradigm comparing healthy adults to patients with ADHD. By including physiological noise regressors into a task-based fMRI analysis, we observed an increase in power in task-relevant regions. At the same time, presumably spurious activation in areas previously associated with physiological noise was diminished. Physiological noise correction for fMRI therefore appears to reduce the risk of interpreting group differences caused by physiological artifacts.

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