Abstract #4131
Reproducibility of Resting-State fMRI Data in Rats across Three Months
Li-Ming Hsu 1 , Jennifer A. Stark 1 , Julia K. Brynildsen 1 , Hong Gu 1 , Hanbing Lu 1 , Elliot A. Stein 1 , and Yihong Yang 1
1
Neuroimaging Research Branch, National
Institute on Drug Abuse, Baltimore, Maryland, United
States
Resting-state fMRI of animal models has the advantage to
assess the trajectory of a disease using longitudinal
paradigms, but the reproducibility of the observations
is critical and less known. Here, we investigate the
reliability of resting fMRI signal of rats in short (10
min), middle (2 weeks) and long (3 months) terms. Our
data showed that the mean ICC across brain networks
during short- or mid-term scans (0.63 and 0.57
respectively) was significantly higher than that of
long-term scans (0.22), suggesting that longitudinal
experiments within weeks would have good
reproducibility, but studies across months should be
practiced with caution under the current conditions.
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