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Abstract #4117

Detection and grading of prostate cancer using model-based spectral fitting

Gregory J. Metzger 1 , Benjamin Fossen 1 , Patrick J. Bolan 1 , Chrisopher Warlick 2 , Badrinath Konety 2 , Stephen C. Schmechel 3 , Chaitanya Kalavagunta 1 , and Ivan Tkac 1

1 Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2 Urologic Surgery, University of Minnesota, Minneapolis, MN, United States, 3 Laboratory Medicine, University of Washington, WA, United States

Model-based fitting of prostate spectra can produce more selective metabolite ratios than conventional peak integration. The model-based ratio tCho/Cit was found to have a strong correlation with cancer aggressiveness (grade), comparable with the standard approach of CSC/Cit ratio, but with the advantage of greater potential selectivity at higher fields.

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