Usefulness of histogram analysis for the investigation of tumour heterogeneity

DCE-MRI and DWI have been used to estimate various physiological parameters on a voxel by voxel basis allowing a full visualisation of the tumour heterogeneity. The methodologies for calculating and interpreting voxel by voxel values are poorly known and may be time-consuming. Unfortunately, mean and median quantitative values are not always significantly sensitive to small changes and may not represent the precise status of the tumour owing to their intrinsic chaotic environment. Owing to advances in both high-resolution MRI and signal processing methods, histogram analyses of tumours showed their usefulness for investigating the distributions of various tumour parameters.

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