Abstract #4088
Optimisation of Time-resolved angiography With Stochastic Trajectories (TWIST) for Dynamic Contrast-Enhanced MRI in Head and Neck Cancer
Rafal Panek 1 , Maria A Schmidt 1 , Marco Borri 1 , Dow-mu Koh 1 , Angela Riddell 2 , Liam Welsh 1 , Ceri Powell 2 , Shreerang A. Bhide 1 , Christopher M. Nutting 3 , Kevin J. Harrington 4 , Kate L. Newbold 1 , and Martin O. Leach 1
1
Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, United Kingdom,
2
Royal
Marsden NHS FT, Sutton, United Kingdom,
3
Royal
Marsden NHS FT, London, United Kingdom,
4
Royal
Marsden NHS FT and Institute of Cancer Research, London,
United Kingdom
The use of the TWIST view-sharing sequence for DCE
pharmacokinetic parameter calculation was investigated.
High temporal resolution DCE data obtained without
view-sharing was used to simulate the effects of
different TWIST k-space undersampling patterns. Absolute
percentage differences of DCE parameters were calculated
for 15 different combinations of sampled central and
peripheral parts of k-space. Calculations were carried
out for a group of H&N cancer patients (n=8) with
varying primary and nodal disease sites to maximize
vascular parameter heterogeneity. Optimal parameters
allowing for reliable DCE calculations using TWIST were
found allowing for high temporal and spatial resolution
measurements in H&N cancer.
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