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Abstract #4088

Optimisation of Time-resolved angiography With Stochastic Trajectories (TWIST) for Dynamic Contrast-Enhanced MRI in Head and Neck Cancer

Rafal Panek 1 , Maria A Schmidt 1 , Marco Borri 1 , Dow-mu Koh 1 , Angela Riddell 2 , Liam Welsh 1 , Ceri Powell 2 , Shreerang A. Bhide 1 , Christopher M. Nutting 3 , Kevin J. Harrington 4 , Kate L. Newbold 1 , and Martin O. Leach 1

1 Royal Marsden NHS FT and Institute of Cancer Research, Sutton, United Kingdom, 2 Royal Marsden NHS FT, Sutton, United Kingdom, 3 Royal Marsden NHS FT, London, United Kingdom, 4 Royal Marsden NHS FT and Institute of Cancer Research, London, United Kingdom

The use of the TWIST view-sharing sequence for DCE pharmacokinetic parameter calculation was investigated. High temporal resolution DCE data obtained without view-sharing was used to simulate the effects of different TWIST k-space undersampling patterns. Absolute percentage differences of DCE parameters were calculated for 15 different combinations of sampled central and peripheral parts of k-space. Calculations were carried out for a group of H&N cancer patients (n=8) with varying primary and nodal disease sites to maximize vascular parameter heterogeneity. Optimal parameters allowing for reliable DCE calculations using TWIST were found allowing for high temporal and spatial resolution measurements in H&N cancer.

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