Abstract #4084
Demonstration of whole body DWI characterisation of tumour heterogeneity for serial response assessment.
Mihaela Rata 1 , Nina Tunariu 1 , Dow M Koh 1 , Stan Kaye 2 , Angela George 3 , Martin O Leach 1 , David J Collins 1 , and Matthew D Blackledge 1
1
Radiotherapy and Imaging, CR-UK and EPSRC
Cancer Imaging Centre, Institute of Cancer Research and
Royal Marsden Hospital, Sutton, Surrey, United Kingdom,
2
Drug
Development Unit, CR-UK and EPSRC Cancer Imaging Centre,
Institute of Cancer Research and Royal Marsden Hospital,
Sutton, Surrey, United Kingdom,
3
Gynaecology
Unit, Royal Marsden Hospital, Sutton, Surrey, United
Kingdom
Intra- or inter- tumour heterogeneity is a major
challenge for anticancer treatment. Our work proposes a
novel whole-body DWI analysis methodology to measure
therapy response in disseminated disease, as exemplified
on a metastatic ovarian cancer patient. The longitudinal
tumour behaviour (over 10 visits) was continuously
assessed during therapy at multiple sites of metastasis.
Such analysis allows full characterization and
visualisation of disease burden and
observation/quantification of individual tumour response
to therapy at each individual site. Histogram and
volumetric assessment of individual lesions provides
additional information regarding treatment compared to
overall assessments of total tumour burden and global
ADC distributions.
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