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Abstract #4081

DCE-MRI and DWI are Sensitive to Vascular Changes in Renal Cell Carcinoma Following Sunitinib Therapy

Dania Daye 1 , Anil Chauhan 1 , Sarah Englander 1 , Thomas Ferrara 1 , Colleen Redlinger 2 , Naomi Haas 2 , Hee-Kwon Song 1 , Stephen Keefe 2 , and Mark Rosen 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Medicine, University of Pennsylvania, Philadelphia, PA, United States

We compared the sensitivity of DCE-MRI and multi-B-value DWI to detect changes in renal cell carcinoma tumor physiology following initiation of anti-angiogenic therapy with Sunitinib. Both DCE-MRI and DWI were able to detect therapy-induced changes in tumor physiology. Statistically significant decreases in tumor permeability and plasma volume (DCE), and fast diffusion component and perfusion fraction (DWI) were shown. Positive correlations were identified between DCE and DWI methods for quantifying baseline RCC tumor vascular physiology, and for detecting vascular changes in RCC tumors early after therapy. DWI can be used as a non-contrast method of tumor vascular monitoring during anti-angiogenic therapy.

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