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Abstract #4069

Cognitive effects of breast cancer therapies: univariate and multivariate analyses of brain connectivity

Scott James Peltier 1 , Marc Berman 2 , Mary Kathleen Askren 3 , Bratislav Misic 4 , Mi Sook Jung 1 , Anthony Randal McIntosh 4 , Lynn Ossher 1 , Min Zhang 1 , Patricia Reuter-Lorenz 1 , and Bernadine Cimprich 1

1 University of Michigan, Ann Arbor, MI, United States, 2 University of South Carolina, SC, United States, 3 University of Washington, WA, United States, 4 University of Toronto, Ontario, Canada

This study investigates resting-state network correlations in women treated for breast cancer and age-matched healthy controls. In addition, a partial-least squares analysis was performed. Univariate and multivariate analyses both exhibited differential patterns of connectivity across groups and time. This may form the basis for improved diagnostic and monitoring techniques for cognitive changes associated with breast cancer and its treatment.

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