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Abstract #4063

Quantitative evaluation of image-based distortion correction in diffusion tensor imaging of the breast

Cheng-Liang Liu 1 , Matthew L Olson 1 , Peixian Liu 1 , Marko K Ivancevic 2 , Constance D Lehman 1 , and Savannah C Partridge 1

1 Department of Radiology, University of Washington, Seattle, Washington, United States, 2 Philips Healthcare, Best, Netherlands

Misalignment within DWI sequences due to eddy-current based distortions in diffusion gradient images reduces the accuracy of computed DWI and DTI parametric maps. Our study in 21 breast cancer patients showed that image-based distortion correction of DTI acquisitions improves spatial alignment and lesion conspicuity and may be essential for quantification of breast DTI parameters beyond ADC.

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