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Abstract #4061

Diffusion Tensor Imaging of the Breast: Hormonal Regulation

Noam Nissan 1 , Edna Furman-Haran 2 , Myra Shapiro-Feinberg 3 , Dov Grobgeld 1 , and Hadassa Degani 1

1 Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 2 Unit of Biological Services, Weizmann Institute of Science, Israel, 3 Meir Medical Center, Kfar Saba, Israel

In this study, we investigated the hormonal regulation of breast diffusion tensor imaging (DTI) throughout the menstrual cycle phases, during lactation and in post-menopause with and without hormonal replacement therapy (HRT). Our findings suggest that DTI parameters are not sensitive to the menstrual cycle changes, while menopause, long term HRT and the presence of milk in lactating women affected DTI parameters. Therefore, the timing for performing breast DTI is not restricted throughout the menstrual cycle, whereas the modulations in diffusion parameters due to HRT and lactation should be taken into account upon DTI evaluation

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