Abstract #4061
Diffusion Tensor Imaging of the Breast: Hormonal Regulation
Noam Nissan 1 , Edna Furman-Haran 2 , Myra Shapiro-Feinberg 3 , Dov Grobgeld 1 , and Hadassa Degani 1
1
Department of Biological Regulation,
Weizmann Institute of Science, Rehovot, Israel,
2
Unit
of Biological Services, Weizmann Institute of Science,
Israel,
3
Meir Medical Center, Kfar Saba,
Israel
In this study, we investigated the hormonal regulation
of breast diffusion tensor imaging (DTI) throughout the
menstrual cycle phases, during lactation and in
post-menopause with and without hormonal replacement
therapy (HRT). Our findings suggest that DTI parameters
are not sensitive to the menstrual cycle changes, while
menopause, long term HRT and the presence of milk in
lactating women affected DTI parameters. Therefore, the
timing for performing breast DTI is not restricted
throughout the menstrual cycle, whereas the modulations
in diffusion parameters due to HRT and lactation should
be taken into account upon DTI evaluation
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