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Abstract #4043

Anti-angiogenic therapy in a murine liver cancer: Complementary assessment with MR-Elastography and Diffusion-Weighted MR imaging

Lauriane Juge 1 , Miguel Albuquerque 2 , Mouniya MEBARKI 2 , Simon A. Lambert 2 , Sabrina Doblas 2 , Shaokoon Cheng 3,4 , Lynne E. Bilston 3,5 , Valerie Paradis 2,6 , Valerie Vilgrain 2 , Bernard E. Van Beers 2 , and Ralph Sinkus 2

1 Neuroscience Research Australia, Randwick, Sydney, NSW, Australia, 2 CRB3-INSERM U773, University Paris Diderot, Paris, France, 3 Neuroscience Research Australia, Randwick, Sydney, Australia, 4 Engineering, Macquarie University, North Ryde, Sydney, Australia, 5 Prince of Wales Clinical School, university of New South Wales, Kensington, Sydney, Australia, 6 Pathology, Beaujon Hospital, Paris, France

Early detection of changes in the vascularity and cellularity of a tumor could represent a significant advance in treatment management using anti-angiogenic agents. We investigated the potential value of MR-Elastography (800, 900 and 1000 Hz) and Diffusion Weighted MR imaging (6 b-values from 0 to 1000 s/mm) in the detection of microstructural changes induced by the therapy (Sorafenib, Nexavar ) in a human liver cancer cell line (HepG2) implanted in immune-deficient mice.. Results showed that potentially, only the biomechanical dispersion properties were sensitive to the changes induced by the anti-angiogenic treatment, while the apparent diffusion properties were not altered.

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