Abstract #4039
Does the presence of micro-vasculature alter the dispersion properties of shear waves? A rat aortic ring model at multiple frequencies using Magnetic Resonance Elastography.
Lauriane Juge 1,2 , Anne Petiet 3 , Simon A. Lambert 2 , Pascal Nicole 2 , Simon Chatelin 2,4 , Sabrina Doblas 2 , Valerie Vilgrain 2,5 , Bernard E. Van Beers 2,5 , and Ralph Sinkus 2,6
1
Neuroscience Research Australia, Randwick,
Sydney, NSW, Australia,
2
CRB3-INSERM
U773, University Paris Diderot, Paris, France,
3
IFR02-CEFI,
University Paris Diderot, Paris, France,
4
Laboratoire
Ondes et Acoustique / Institut Langevin, ESPCI, Paris,
France,
5
Radiology,
Beaujon Hospital, Clichy, Paris, France,
6
Division
of Imaging Sciences and Biomedical Engineering, Kings
College London, Kings Health Partners, St. Thomas
Hospital, London, United Kingdom
Disease or therapies can change the mechanical integrity
and organization of vascular structures. If blood
vessels represent a source for wave scattering, Magnetic
Resonance Elastography (MRE) should be able to sense
these changes. Considering the hypothesis that the
presence of an underlying fractal-like stiff structure
is capable of generating on the macroscopic scale power
law behavior, multi-frequency MRE (100-150Hz) was
performed to quantify alteration of the shear wave speed
due to the presence of vascular outgrowth using a rat
aortic ring model. Results support the ability of using
shear wave diffusion parameters to probe the structure
of the vascular bed.
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