Abstract #4010
ROLE OF MACROPHAGIC HIFs IN THE RESOLUTION OF INFLAMMATION DURING SKELETAL MUSCLE REGENERATION: A COMBINED IN VITRO, EX VIVO AND MULTIMODAL MRI INVESTIGATION
JULIEN GONDIN 1 , GUILLAUME DUHAMEL 1 , MARINE THERET 2 , KATARINA PEGAN 3 , CAROLE PEYSSONNAUX 2 , SYLVAIN CUVELLIER 2 , BENEDICTE CHAZAUD 2 , DAVID BENDAHAN 1 , and REMI MOUNIER 2
1
Aix-Marseille University, CNRS, CRMBM UMR
7339, MARSEILLE, France,
2
INSERM,
U1016; CNRS, UMR8104; Universit Paris Descartes,
Institut Cochin, PARIS, France,
3
Institute
of Pathophysiology, Faculty of Medicine, University of
Ljubljana, LJUBLJANA, Slovenia
We aimed at carefully addressing the role of myeloid
HIFs in the resolution of inflammation during skeletal
muscle regeneration on the basis of in vitro and ex vivo
experiments combined to in vivo multimodal magnetic
resonance imaging (MRI), including T2 mapping and
diffusion tensor imaging. Our multiscale methodological
approach clearly demonstrated that neither HIF-1α nor
HIF-2α are involved in the muscle regeneration process
resulting from an acute injury, thereby indicating that
myeloid HIFs are dispensable for skeletal muscle
regeneration. We also reported that multimodal MRI
appears as a method of choice for monitoring skeletal
muscle injury and repair.
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