Abstract #4008
MR supports therapeutic effects of corticosteroids in 5-7 year old boys with DMD
Ishu Arpan 1 , Rebecca Willcocks 1 , Sean Forbes 1 , Donovan Lott 1 , Claudia Senesac 1 , William Triplett 1 , Michael Daniels 2 , Barry Byrne 3 , Bill Rooney 4 , Erika Finanger 4 , Richard Finkel 5 , Barry Russman 4,6 , Gihan Tennekoon 5 , Dah-Jyuu Wang 7 , Glenn Walter 8 , H. Lee Sweeney 9 , and Krista Vandenborne 1
1
Physical Therapy, University of Florida,
Gainesville, Florida, United States,
2
University
of Texas, Texas, United States,
3
Pediatrics
and Molecular Genetics & Microbiology, University of
Florida, Gainesville, Florida, United States,
4
Oregon
Health & Science University, Oregon, United States,
5
Neurology,
The Childrens Hospital of Philadelphia, Pennsylvania,
United States,
6
Shriners
Hospital for Children, Oregon, United States,
7
Radiology,
The Childrens Hospital of Philadelphia, Pennsylvania,
United States,
8
Physiology
and Functional Genomics, University of Florida,
Gainesville, Florida, United States,
9
Physiology,
University of Pennsylvania, Pennsylvania, United States
The aim of this study was to evaluate impact of
corticosteroids on lower extremity muscles of 5-7 year
old boys with DMD using MRI and MRS. 15 boys with DMD on
corticosteroids and 15 age-matched corticosteroid-naive
boys were recruited. Inherent MR relaxation properties
of muscle (T
2
by
imaging and spectroscopy) and lipid fraction were
measured. MRI/MRS results showed that T
2
values
and fat fraction were lower in muscles of boys in
treatment group; suggesting reduced inflammation/ damage
and fat infiltration with corticosteroid treatment.
Further, there was less change in fat fraction over one
year in muscles of boys taking corticosteroids.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
