Abstract #3998
In-Vivo Assessment of Multiple Water Components of Human Knee Menisci using mcDESPOT at 3.0T
Fang Liu 1 , Wally Block 1,2 , and Richard Kijowski 3
1
Department of Medical Physics, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
2
Department
of Biomedical Engineering, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
3
Department
of Radiology, University of Wisconsin-Madison,
Wisconsin, United States
In-vivo multi-component T2 mapping of menisci using
mcDESPOT was performed on asymptomatic volunteers and
patients with osteoarthritis at 3.0T. Meniscus has a
slowly relaxing water component with a T2 relaxation
time of 30.9 ms and a rapidly relaxing water component
with a T2 relaxation time of 10.3 ms. Our study has
documented a decreased rapid relaxing water component
fraction and an increased T2 relaxation time of meniscus
in patients with OA when compared to healthy volunteers
with greater changes associated with more severe
meniscal degeneration (i.e. tearing) and more severe
joint degeneration (i.e. higher WORM score).
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