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Abstract #3996

gagCEST MRI: A potential biomarker for post-surgery follow-up of patients with anterior cruciate ligament reconstruction

Olgica Zaric 1 , Pavol Szomolanyi 1 , Vladimir Mlynarik 1 , Mark Schurz 2 , Stefanie Syre 2 , Thomas Tiefenbck 2 , Manuela Karner 1 , and Siegfried Trattnig 1

1 Department of Biomedical Imaging and Image-guided Therapy, Medical University in Vienna, Vienna, Austria, Austria, 2 Trauma Surgery Department, Medical University in Vienna, Vienna, Austria, Austria

The aim of this study was to investigate the feasibility of gagCEST imaging and T2* mapping in post-surgery follow-up of biochemical and morphological properties of reconstructed tissue in the patients with anterior cruciate ligament substitution. Results showed an increase of gagCEST effect (related to total glycosaminoglycan content in the tissue) from early to late post-surgery period, while T2* (related to collagen architecture network) showed a significant decrease. Based on this initial results, we conclude that gagCEST has a great potential as biomarker in investigation of properties of newly developed ligament tissue in patients after ACL reconstruction.

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