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Abstract #3990

In Vivo MR Computation of Whole Proximal Femur Mechanical Competence Using Micro-Finite Element Analysis Applied to High-Resolution 3T MRI of Proximal Femur Microarchitecture

Alexandra Hotca 1,2 , Chamith S. Rajapakse, PhD 3 , Henry Rusinek, PhD 4 , Stephen Honig, MD 5 , Ryan Brown, PhD 6 , Cem M. Deniz, PhD 6 , Ravinder R. Regatte, PhD 6 , and Gregory Chang, MD 1

1 Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, New York, NY, United States, 2 Department of Biological Sciences, CUNY-Hunter College, New York, NY, United States, 3 Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, United States, 4 Department of Radiology, New York University School of Medicine, New York, NY, United States, 5 Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, New York, NY, United States, 6 Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, NY, United States

In this study, micro-finite element analysis (μFEA) is applied to high-resolution 3T MR images of proximal femur microarchitecture to quantitatively assess the mechanical competence (stiffness) of the whole proximal femur in vivo. Bone microarchitecture is understood to be a critical determinant of bone strength. The results of this study show that μFEA can be used to detect reduced whole proximal femur stiffness in subjects with osteoporotic fractures compared to controls without fracture who do not differ by bone mineral density. This warrants a larger study to confirm these trends.

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