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Abstract #3987

Multi-Component T2 Analysis of Articular Cartilage in Osteoarthritis Patients using mcDESPOT at 3.0T

Fang Liu 1 , Richard G. Spencer 2 , Wally Block 1,3 , and Richard Kijowski 4

1 Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, United States, 2 Magnetic Resonance Imaging and Spectroscopy Section, National Institutes on Health, Baltimore, Maryland, United States, 3 Department of Biomedical Engineering, University of Wisconsin-Madison, madison, Wisconsin, United States, 4 Department of Radiology, University of Wisconsin-Madison, Wisconsin, United States

Multi-Component T2 mapping using mcDESPOT two pool model was performed for ten asymptomatic volunteers and fourteen patients with varying degrees of osteoarthritis. The water fraction for water tightly bound to proteoglycan (FPG ) was significantly lower on all articular surfaces of the knee joint in patients with osteoarthritis than asymptomatic volunteers which likely reflect the decreased proteoglycan content of degenerative cartilage. FPG had greater statistical power than single component T2 (T2single ) for distinguishing between asymptomatic volunteers and patients with osteoarthritis especially on articular surfaces with early cartilage degeneration.

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