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Abstract #3983

Clinical feasibility of a stimulated echo based diffusion sequence and correlation between T1rho and diffusion values

Aditi Guha 1 , Cory Wyatt 1 , Dimitrios Karampinos 1,2 , Lorenzo Nardo 1 , Thomas M Link 1 , and Sharmila Majumdar 1

1 Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2 Radiology, Technische Universitt Mnchen, Germany

Osteoarthritis (OA) is a common degenerative disorder, which occurs due to wear and tear of the joint. Research has shown that subtle changes in tissue microstructure correlate with changes in restricted diffusion of water, which manifest in signal changes on diffusion-weighted MR images. A new pulse sequence for diffusion weighted imaging of the knee combining stimulated echo diffusion preparation with magnetization prepared angle modulated partitioned k-space spoiled gradient echo snapshots (MAPSS) acquisition for diffusion imaging of short T2 tissues like cartilage at 3T is investigated. We also look at the correlation between two potential biomarkers for OA: diffusion and T1ρ.

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