Abstract #3965
Beyond Edema: Myocardial T2 in Chronic Myocardial Infarction Swine
Haiyan Ding 1,2 , Karl H. Schuleri 3 , Henry Halperin 2,3 , Roy Beinart 3,4 , M. Muz Zviman 3 , and Daniel A. Herzka 2
1
Department of Biomedical Engineering,
Tsinghua University, Beijing, China,
2
Department
of Biomedical Engineering, Johns Hopkins School of
Medicine, Baltimore, MD, United States,
3
Department
of Medicine, Division of Cardiology, Johns Hopkins
School of Medicine, Baltimore, MD, United States,
4
Heart
Institute, Sheba Medical Center, Tel Aviv University,
Ramat Gan, Israel
T2 relaxation time correlates with pathologic processes
within myocardial tissue. Recently, quantitative T2
mapping has been shown more robust than qualitative
clinical T2-weighted imaging in many diseases though
most effort has been directed at acute injury and
visualization of edema. Chronic myocardial infarction
(MI) affects both water and collagen content that in
turn impacts relaxation times. We hypothesize that
quantitative T2 measurements may characterize infarct in
chronic MI without extraneous contrast agent. A swine
model was studied with both in vivo MRI and ex vivo
histology. We demonstrate that myocardial T2 mapping has
the potential to noninvasively characterize chronic MI
without exogenous contrast agents.
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