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Abstract #3965

Beyond Edema: Myocardial T2 in Chronic Myocardial Infarction Swine

Haiyan Ding 1,2 , Karl H. Schuleri 3 , Henry Halperin 2,3 , Roy Beinart 3,4 , M. Muz Zviman 3 , and Daniel A. Herzka 2

1 Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2 Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, 3 Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, 4 Heart Institute, Sheba Medical Center, Tel Aviv University, Ramat Gan, Israel

T2 relaxation time correlates with pathologic processes within myocardial tissue. Recently, quantitative T2 mapping has been shown more robust than qualitative clinical T2-weighted imaging in many diseases though most effort has been directed at acute injury and visualization of edema. Chronic myocardial infarction (MI) affects both water and collagen content that in turn impacts relaxation times. We hypothesize that quantitative T2 measurements may characterize infarct in chronic MI without extraneous contrast agent. A swine model was studied with both in vivo MRI and ex vivo histology. We demonstrate that myocardial T2 mapping has the potential to noninvasively characterize chronic MI without exogenous contrast agents.

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