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Abstract #3954

Non-contrast MRI characterization of thrombus composition and susceptibility to thrombolysis in a mouse model of deep vein thrombosis.

Marcelo E Andia 1 , Alkystis Phininkaridou 2 , Prakash Saha 3 , Bijan Modarai 3 , Alberto Smith 3 , and Rene M Botnar 2

1 Radiology Deparment, Pontificia Universidad Catolica de Chile, Santiago, Santiago, Chile, 2 Division of Imaging Sciences and Biomedical Engineering, Kings College London, London, United Kingdom, 3 Academic Department of Surgery, Kings College London, London, United Kingdom

In vivo evaluation of the stage of organization of venous thrombosis could help guide medical treatment and intervention. We have previously demonstrated that magnetization transfer ratio (MTR), T1 mapping and apparent diffusion coefficient (ADC) sequences detect the concentration and spatial distribution of collagen and methemoglobin, and proton diffusivity of the thrombus, respectively. In this work we studied if these MR parameters could improve the identification of thrombus suitable for thrombolytic treatment.

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