Abstract #3952
Prognostic CMR parameters for heart failure and arrhythmias in large cohort of well treated thalassemia major patients
Antonella Meloni 1 , Vincenzo Positano 1 , Giuseppe Rossi 2 , Petra Keilberg 1 , Silvia Macchi 3 , Antonella Carollo 4 , Valentina Vinci 5 , Paolo Preziosi 6 , Cristina Salvatori 1 , Massimo Lombardi 1 , and Alessia Pepe 1
1
CMR Unit, Fondazione G.Monasterio
CNR-Regione Toscana and Institute of Clinical
Physiology, Pisa, Italy,
2
Epidemiology
and Biostatistics Unit, Institute of Clinical
Physiology, CNR, Pisa, Italy,
3
Servizio
Trasfusionale, Ospedale Santa Maria delle Croci,
Ravenna, Italy,
4
Servizio
Talassemia-U.O. Pediatria Talassemia, Az. Osp. "Sant'Antonio
abate", Trapani, Italy,
5
Istituto
di Radiologia, Az. Osp. "Garibaldi" Presidio Ospedaliero
Nesima, Catania, Italy,
6
U.O.C.
Diagnostica per Immagini e Interventistica, Policlinico
Casilino", Roma, Italy
This study aimed to determine the predictive value of
CMR parameters for heart failure and arrhythmias in
thalassemia major. Thanks to a MR-guided,
patient-specific adjustment of the chelation therapy,
few cardiac events were detected. Severe and homogeneous
MIO, myocardial fibrosis and ventricular dysfunction
identify patients at high risk of heart failure. Heart
T2* doesnt have any power in predicting arrhythmias
while male sex and atrial dilation are independent
prognosticators.
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