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Abstract #3942

3D Fractal Analysis of Pulmonary MRA distinguishes Pulmonary Arterial Hypertension Patients from Normal Volunteers

Phillip Kilgas 1 , Eric Schrauben 2 , Alejandro Roldan-Alzate 1 , Oliver Wieben 2 , Naomi Chesler 3 , Christopher Franois 1 , and Mark L. Schiebler 1

1 Radiology, UW-Madison, Madison, WI, United States, 2 Medical Physics, UW-Madison, Madison, WI, United States, 3 Biomedical Engineering, UW-Madison, Madison, WI, United States

Pulmonary arterial hypertension (PAH) is a rapidly progressive disease. As a result of elevated pulmonary arterial pressures, pruning of the number of small pulmonary artery occurs [1]. Quantification of this pruning may provide a biomarker independent of vessel size for this disease and could lessen the need for invasive catheter based measurements. We have found that 3D fractal analysis of the pulmonary arterial branching pattern, derived from MRA examinations, is an independent variable that can be used to diagnose the presence of pulmonary arterial hypertension.

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