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Abstract #3916

Longitudinal relaxation time and apparent diffusion coefficient in human carotid plaque at 3T: phantom validation and histological comparison

Hideki Ota 1 , Mika Watanabe 2 , Tatsuo Nagasaka 3 , Makoto Obara 4 , and Hajime Tamura 5

1 Diagnostic Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan, 2 Pathology, Tohoku University Hospital, Sendai, Miyagi, Japan, 3 Radiology, Tohoku University Hospital, Sendai, Miyagi, Japan, 4 Philips Electronics Japan, Tokyo, Japan, 5 Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

We optimized a 3-dimensional double-angle Look-Locker and outer volume suppression diffusion weighted imaging sequences to quantify longitudinal relaxation rate (R1) and apparent diffusion coefficient (ADC) of human carotid plaque components. We measured R1 and ADC of histologically-confirmed plaque components such as lipid core, hemorrhage and fibrous tissue. Our result indicated that the combination of R1 and ADC enabled objective segmentation of carotid plaque components.

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