Abstract #3914
High quality 7T MRI of atherosclerotic plaque in the significantly stenosed carotid artery
Alexandra A.J. de Rotte 1 , Wouter Koning 2 , Martine T.B. Truijman 3,4 , Anne G. den Hartog 5 , Sandra M. Bovens 6 , Aryan Vink 7 , Shahrzad Sepehrkhouy 7 , Jaco J.M. Zwanenburg 8 , Dennis W.J. Klomp 8 , Gerard Pasterkamp 9 , Frans L. Moll 5 , Peter L. Luijten 8 , Jeroen Hendrikse 8 , and Gert Jan de Borst 5
1
Radiology, University Medical Center
Utrecht, Utrecht, Utrecht, Netherlands,
2
University
Medical Center Utrecht, Utrecht, Netherlands,
3
Radiology
and Clinical Neurophysiology, Maastricht University
Medical Center, Limburg, Netherlands,
4
Cardiovascular
Research Institute Maastricht, Limburg, Netherlands,
5
Vascular
Surgery, University Medical Center Utrecht, Utrecht,
Netherlands,
6
Bioengineering,
Imperial College London, London, United Kingdom,
7
Pathology,
University Medical Center Utrecht, Utrecht, Netherlands,
8
Radiology,
University Medical Center Utrecht, Utrecht, Netherlands,
9
Experimental
Cardiology, University Medical Center Utrecht, Utrecht,
Netherlands
This is the first study showing the feasibility of
carotid plaque imaging at 7T in a series of patients
with a symptomatic carotid artery stenosis of >70%. The
available BB sequences at 7T seem accurate to
demonstrate that an increasing hyperintensity of the MR
signal in the carotid plaque on the PDW sequence is
inversely proportional to the absence of calcification
in the atherosclerotic plaque. Carotid plaque MRI at 7T
enables to increase SNR significantly, compared to 3T,
which results in accurate luminal and vessel wall
determination, both in healthy volunteers and in a
series of high-risk patients.
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