Meeting Banner
Abstract #3911

3D dynamic contrast enhanced (DCE) MRI of atherosclerotic plaques: image quality, temporal stability and ex vivo validation in a rabbit model

Claudia Calcagno 1 , Mark E Lobatto 1 , Philip M Robson 1 , Olivier Lairez 1 , Max Senders 1 , Alexandra Black 1 , Sarayu Ramachandran 1 , Willem JM Mulder 1,2 , Venkatesh Mani 1 , and Zahi A Fayad 1

1 Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2 Amsterdam Medical Center, Amsterdam, The Netherlands, Netherlands

Abundant, permeable microvasculature is a hallmark of high-risk atherosclerotic plaques, and can be quantified using non-invasive 2D dynamic contrast enhanced (DCE) MRI. Current 2D DCE-MRI acquisitions suffer from several limitations. Here we compare 3D turbo field echo (TFE) and turbo spin echo (TSE) DCE-MRI with extensive spatial coverage in atherosclerotic rabbits. We find that 3D TFE DCE-MRI has higher temporal stability than 3D TSE DCE-MRI, and allows for comparable vessel wall/lumen delineation. Furthermore we find that in vivo permeability by 3D TFE DCE-MRI correlates significantly with ex vivo permeability by ex vivo Evans Blue fluorescence.

This abstract and the presentation materials are available to members only; a login is required.

Join Here